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Did you mean cams and liver (830 results)?
De novo NAD+ synthesis enhances mitochondrial function and improves health.
Katsyuba E, Mottis A, Zietak M, De Franco F, van der Velpen V, Gariani K, Ryu D, Cialabrini L, Matilainen O, Liscio P, Giacchè N, Stokar-Regenscheit N, Legouis D, de Seigneux S, Ivanisevic J, Raffaelli N, Schoonjans K, Pellicciari R, Auwerx J. Katsyuba E, et al. Nature. 2018 Nov;563(7731):354-359. doi: 10.1038/s41586-018-0645-6. Epub 2018 Oct 24. Nature. 2018. PMID: 30356218 Free PMC article.
We also characterize two potent and selective inhibitors of ACMSD. Because expression of ACMSD is largely restricted to kidney and liver, these inhibitors may have therapeutic potential for protection of these tissues from injury. In summary, we identify A …
We also characterize two potent and selective inhibitors of ACMSD. Because expression of ACMSD is largely restricted to kidney …
Dietary linoleic acid suppresses gene expression of rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) and increases quinolinic acid in serum.
Egashira Y, Sato M, Tanabe A, Saito K, Fujigaki S, Sanada H. Egashira Y, et al. Adv Exp Med Biol. 2003;527:671-4. doi: 10.1007/978-1-4615-0135-0_79. Adv Exp Med Biol. 2003. PMID: 15206789
We previously reported that ingestion of polyunsaturated fatty acids by rats leads to a decrease in their hepatic ACMSD activity. We purified ACMSD and cloned cDNA encoding rat ACMSD. ...In the rats fed with linoleic acid, ACMSD mRNA and its protein le …
We previously reported that ingestion of polyunsaturated fatty acids by rats leads to a decrease in their hepatic ACMSD activity. We …
Differential effects of dietary fatty acids on rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase activity and gene expression.
Egashira Y, Murotani G, Tanabe A, Saito K, Uehara K, Morise A, Sato M, Sanada H. Egashira Y, et al. Biochim Biophys Acta. 2004 Nov 8;1686(1-2):118-24. doi: 10.1016/j.bbalip.2004.04.010. Biochim Biophys Acta. 2004. PMID: 15522828
We previously purified ACMSD and cloned cDNA encoding rat ACMSD. Therefore, in this study, we examined the differential effect of fatty acids on ACMSD mRNA expression by Northern blot. ...When diets containing 2% level of fatty acid were given to male Sprague …
We previously purified ACMSD and cloned cDNA encoding rat ACMSD. Therefore, in this study, we examined the differential effect …
Structural Basis of Human Dimeric α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025.
Cianci M, Giacchè N, Cialabrini L, Carotti A, Liscio P, Rosatelli E, De Franco F, Gasparrini M, Robertson J, Amici A, Raffaelli N, Pellicciari R. Cianci M, et al. Front Mol Biosci. 2022 Apr 7;9:834700. doi: 10.3389/fmolb.2022.834700. eCollection 2022. Front Mol Biosci. 2022. PMID: 35463964 Free PMC article.
Human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) stands at a branch point of the de novo NAD(+) synthesis pathway and plays an important role in maintaining NAD(+) homeostasis. ...The results provide new structural information about the mec …
Human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) stands at a branch point of the de novo NAD(+) synt …
Purification and molecular cloning of rat 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase.
Tanabe A, Egashira Y, Fukuoka S, Shibata K, Sanada H. Tanabe A, et al. Biochem J. 2002 Feb 1;361(Pt 3):567-75. doi: 10.1042/0264-6021:3610567. Biochem J. 2002. PMID: 11802786 Free PMC article.
In the present study, we purified the enzyme from rat liver and kidney, and cloned the cDNA encoding rat ACMSD. The molecular masses of rat ACMSDs purified from the liver and kidney were both estimated to be 39 kDa by SDS/PAGE. ...ACMSD was expressed i …
In the present study, we purified the enzyme from rat liver and kidney, and cloned the cDNA encoding rat ACMSD. The molecular …
Down-regulation of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARalpha.
Sasaki N, Egashira Y, Sanada H. Sasaki N, et al. Eur J Nutr. 2008 Mar;47(2):80-6. doi: 10.1007/s00394-008-0699-6. Epub 2008 Mar 4. Eur J Nutr. 2008. PMID: 18320257
BACKGROUND: alpha-Amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is a key enzyme in NAD biosynthesis from tryptophan. Dietary polyunsaturated fatty acids (PUFA) have been shown to suppress hepatic ACMSD activity and its mRNA level in rat. ...A …
BACKGROUND: alpha-Amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is a key enzyme in NAD biosynthesis from tryp …
Adult zebrafish as an in vivo drug testing model for ethanol induced acute hepatic injury.
Park KH, Kim SH. Park KH, et al. Biomed Pharmacother. 2020 Dec;132:110836. doi: 10.1016/j.biopha.2020.110836. Epub 2020 Oct 6. Biomed Pharmacother. 2020. PMID: 33035832 Free PMC article.
Chronic alcohol abuse is common and a leading cause of alcoholic liver disease (ALD). However, a safe and effective therapy for ALD is still elusive. ...Accompanying this, significant increases in mRNA expression of genes associated with inflammation was observed in the …
Chronic alcohol abuse is common and a leading cause of alcoholic liver disease (ALD). However, a safe and effective therapy for ALD i …
Alpha-Amino-Beta-Carboxy-Muconate-Semialdehyde Decarboxylase Controls Dietary Niacin Requirements for NAD+ Synthesis.
Palzer L, Bader JJ, Angel F, Witzel M, Blaser S, McNeil A, Wandersee MK, Leu NA, Lengner CJ, Cho CE, Welch KD, Kirkland JB, Meyer RG, Meyer-Ficca ML. Palzer L, et al. Cell Rep. 2018 Oct 30;25(5):1359-1370.e4. doi: 10.1016/j.celrep.2018.09.091. Cell Rep. 2018. PMID: 30380424 Free PMC article.
We show that transgenic mice with inducible expression of human alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) become niacin dependent similar to humans when ACMSD expression is high. ...NAD deficiency in mice contributed to behavioral and heal …
We show that transgenic mice with inducible expression of human alpha-amino-beta-carboxy-muconate-semialdehyde decarboxylase (ACMSD) …
Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism.
Pucci L, Perozzi S, Cimadamore F, Orsomando G, Raffaelli N. Pucci L, et al. FEBS J. 2007 Feb;274(3):827-40. doi: 10.1111/j.1742-4658.2007.05635.x. FEBS J. 2007. PMID: 17288562 Free article.
Through an isoform-specific real-time PCR assay, the constitutive expression of two alternatively spliced ACMSD transcripts (ACMSD I and II) has been examined in human brain, liver and kidney. Both transcripts are present in kidney and liver, with high …
Through an isoform-specific real-time PCR assay, the constitutive expression of two alternatively spliced ACMSD transcripts (ACMSD …
The effect of 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase gene overexpression in the kynurenine pathway on the expression levels of indoleamine 2,3-dioxygenase 1 and interferon-γ in inflammatory conditions: an in vitro study.
Rostaminejad M, Rostami A, Behzad-Behbahani A, Dehbidi GRR, Kalantari T. Rostaminejad M, et al. Mol Biol Rep. 2022 Feb;49(2):1103-1111. doi: 10.1007/s11033-021-06935-4. Epub 2021 Nov 14. Mol Biol Rep. 2022. PMID: 34775574
METHODS AND RESULTS: The coding sequence of the Acmsd gene was cloned into pCMV6-AC-IRES-GFP expression vector with a green fluorescent protein (GFP) marker. ...CONCLUSIONS: Acmsd gene overexpression in inflammatory conditions can reduce the expression levels of the …
METHODS AND RESULTS: The coding sequence of the Acmsd gene was cloned into pCMV6-AC-IRES-GFP expression vector with a green fluoresce …
32 results